Bibliografia Linea Biotic

GSE BIOTIC

GSE BIOTIC FORTE

-      Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002 Jun; 8(3):333-40

-      Cvetnić Z, Vladimir-Knezević S. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharm. 2004 Sep; 54(3):243-50

-      Zanotti Simões Dourado GK, de Abreu Ribeiro LC, Zeppone Carlos I, Borges César T. Orange Juice and Hesperidin Promote Differential Innate Immune Response in Macrophages ex vivo. Int J Vitam Nutr Res. 2013 Giugno; 83(3):162–7

-      Sharamon S, Baginski BJ. Le virtù terapeutiche dei semi di Pompelmo. Tecniche Nuove, Milano, 2004

-      Al-Ani WN, Tawfih NOM, Shehab EY: Antimicrobial activity of grapefruit seeds extracts (In vitro study). Al-Rafidain Dental Journal 2011, 11(2):341-345.

-      Joshi R, Kulkarni YA, Wairkar S. Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update. Life Sci. 2018; 215:43-56.
-      8: Xu H, Kulkarni KH, Singh R, et al. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009;6(6):1703-1715.

-      V. Verardo et al., “Bioactive Components in Fermented Foods and Food By-Products”, Foods 2020

-      Verni, M.; Verardo, V.; Rizzello, C.G. How Fermentation Affects the Antioxidant Properties of Cereals and Legumes. Foods 2019.

-      Doan, D.T.; Luu, D.P.; Nguyen, T.D.; Hoang Thi, B.; Pham Thi, H.M.; Do, H.N.; Luu, V.H.; Pham, T.D.; Than, V.T.; Pham Thi, H.H.; et al. “Isolation of Penicillium citrinum from Roots of Clerodendron cyrtophyllum and Application in Biosynthesis of Aglycone Isoflavones from Soybean Waste Fermentation”. Foods 2019

-      Sevgili, A.; Erkmen, O. Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora. Foods 2019.

-      Enbo Xu, Zhengzong Wu et al., “Calcium—lactate-induced enzymatic hydrolysis of extruded broken rice starch to improve Chinese rice wine fermentation and antioxidant capacity” Food Science and Technology, 2019.

-      Mauro Fisberg e Rachel Machado “History of yogurt and current patterns of consumption”, Nutrition

-      N. Pazyar et al, A review of applications of tea tree oil in dermatology, The International Society of Dermatology, 2012

-      Miloš Nikolic et al., Screening of antimicrobial and antioxidant activity of commercial Melaleuca alternifolia (tea tree) essential oils, Journal of Medicinal Plants Research, 2012
-      Nader Pazyar et al., A review of applications of tea tree oil in dermatology. The International Society of Dermatology, 2012

-      C. F. Carson. Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties, CLINICAL MICROBIOLOGY REVIEWS, 2006
-      EMA, European Union herbal monograph on Melaleuca alternifolia (Maiden and Betch) Cheel, M. linariifolia Smith, M. dissitiflora F. Mueller and/or other species of Melaleuca, aetheroleum , 2015

-      E. Ernst A. Huntley, Tea Tree Oil: A Systematic Review of Randomized Clinical Trials, Research in Complementary Medicine, 2000.

-      K.A. Hammer et al., A review of the toxicity of Melaleuca alternifolia- Tea tree- oil, Food and Chemical Toxicology 44; 2006

-      Vazquez, J. A., and A. A. Zawawi. 2002. Efficacy of alcohol-based and alcohol-free melaleuca oral solution for the treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS. HIV Clin. Trials 3:379–385.

-      Garozzo et al., Activity of Melaleuca alternifolia (Tea tree) on Influenza virus A/PR/8: Study on mechanism of action, Antiv Research, 2010

-      Luca Fortuna, Aromaterapia naturopatica. Edizioni Enea.

-      F. Firenzuoli, Fitoterapia. Guida all’uso delle piante medicinali. Edra Spa Editore.

-      Assessment report on Echinacea angustifolia DC., radix– 27 Marzo 2012 EMA - Committee on Herbal Medicinal Products (HMPC)

-      Testo atlante di Fitoterapia – Max Wichtl Ed. Italiana 2002 per UTET a cura di Roberto Della Loggia, pp. 179-182

-      Clinical Overview – Echinacea- The ABC Clinical Guide to Herbs, pp. 85-96
-      R. Maffei Facino et al.; Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage – Planta Med; 61(1995)510

-      F. Firenzuoli, Fitoterapia. Guida all’uso delle piante medicinali. Edra Spa Editore.
-      WHO. Echinacea. In: WHO monographs on selected medicinal plants. Geneva: World Health Organization, 1999: 125–44.

-      Sachin A Shah et al. Evaluation of Echinacea for the prevention and treatment of the common cold: a meta-analysis, Lancet Infect Dis 2007

-      Michael Gallo, Pregnancy outcome following gestational exposure to Echinacea, American Medical Association, 2000.

-      Linda S. Kim, Immunological Activity of Larch Arabinogalactan and Echinacea: A Preliminary, Randomized, Double-blind, Placebo-controlled Trial, Altern Med Rev 2002;7(2):138-149

-      Matthias et al, Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations, Phytomedicine , 2007, Pages 587-590

-      Pleschka, S., et al. Anti-Viral Properties and Mode of Action of Standardized Echinacea Purpurea Extract against Highly Pathogenic Avian Influenza Virus (H5N1, H7N7) and Swine-Origin H1N1 (S-OIV). Virology Journal,(2009)

-      S M Sharma et al. Bactericidal and anti-inflammatory properties of a standardized Echinacea extract (Echinaforce): dual actions against respiratory bacteria, Phytomedicine, 2010

-      EMA/HMPC/557979/2013 Committee on Herbal Medicinal Products (HMPC) Assessment report on Echinacea purpurea (L.) Moench., herba recens24 November 2014

-      M. Jawad et al, Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial, Evidence-Based Complementary and Alternative Medicine, 2012

-      Saunders et al, Echinacea purpurea L. in children: safety, tolerability, compliance and clinical effectiveness in upper respiratory tract infections. Can J. Physiol. Pharmacol. 2007

-      Michael Gallo, Pregnancy outcome following gestational exposure to Echinacea, American Medical Association, 2000.

-      Roger A Burger, Anthony R.Torres et al., Echinacea-induced cytokine production by human macrophages, International Journal of Immunopharmacology, 1997

-      Matthias et al, Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations, Phytomedicine , 2007, Pages 587-590

-      M. Stimpel, Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infection and Immunity, 1984

-      Juerg Gertsch et al., Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways, FEBS let, 2004

-      Xiao-HuGan et al, Mechanism of activation of human peripheral blood NK cells at the single cell level by Echinacea water soluble extracts: recruitment of lymphocyte–target conjugates and killer cells and activation of programming for lysis, International Immunopharmacology, Volume 3, Issue 6, June 2003

-      B. Schulten, Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial. Arzneimittelforschung, 2001

-      Goel at al, Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther, 2004

-      Wendy Weber et al., Echinacea purpurea for Prevention of Upper Respiratory Tract Infections in Children. The Journal of Alternative and Complementary Medicine Vol. 11, No. 6 Original Paper, 2005

-      PDR, Physicians’ Desk Reference, CEC Editore, 2010

-      Wapnir RA & Stiel L. Zinc intestinal absorption in rats: specificity of amino acids as ligands. Journal of Nutrition. 1986; 116:2171–2179.

-      Maria Maares, Hajo Haase. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients 2020.

-      IV Revisione dei Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana (LARN). Società Italiana di Nutrizione Umana (SINU). 2014

-      Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017 Nov 25;9(12):1286.

-      Skrajnowska D, Bobrowska-Korczak B. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients. 2019 Sep 22;11(10):2273.

-      Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998 Aug;68(2 Suppl):447S-463S.

-      Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol. 1976 Apr;18(1):298-306.

-      Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019 Jul 1;10(4):696-710.

-      Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S, Black RE: Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004; 363: 1683–1688.

-      Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94.

-      Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013 Jun 18;(6):CD001364. Update in: Cochrane Database Syst Rev. 2015;(4):CD001364.

-      Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK, Fernández-Larrea JB. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem. 2014 Aug 13;62(32):8085-93.

-      Clergeaud G, Dabbagh-Bazarbachi H, Ortiz M, Fernández-Larrea JB, O'Sullivan CK. A simple liposome assay for the screening of zinc ionophore activity of polyphenols. Food Chem. 2016 Apr 15;197(Pt A):916-23.

-      Maares M, Haase H. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients. 2020 Mar 13;12(3):762.

-      Wapnir RA, Stiel L. Zinc intestinal absorption in rats: Specificity of amino acids as ligands. J Nutr . 1986; 116:2171-2179.

GSE BIOTIC BABY 3-12

-      Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002 Jun; 8(3):333-40

-      Cvetnić Z, Vladimir-Knezević S. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharm. 2004 Sep; 54(3):243-50

-      Zanotti Simões Dourado GK, de Abreu Ribeiro LC, Zeppone Carlos I, Borges César T. Orange Juice and Hesperidin Promote Differential Innate Immune Response in Macrophages ex vivo. Int J Vitam Nutr Res. 2013 Giugno; 83(3):162–7

-      Sharamon S, Baginski BJ. Le virtù terapeutiche dei semi di Pompelmo. Tecniche Nuove, Milano, 2004

-      Al-Ani WN, Tawfih NOM, Shehab EY: Antimicrobial activity of grapefruit seeds extracts (In vitro study). Al-Rafidain Dental Journal 2011, 11(2):341-345.

-      Joshi R, Kulkarni YA, Wairkar S. Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update. Life Sci. 2018; 215:43-56.

-      Xu H, Kulkarni KH, Singh R, et al. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009;6(6):1703-1715.

-      V. Verardo et al., “Bioactive Components in Fermented Foods and Food By-Products”, Foods 2020

-      Verni, M.; Verardo, V.; Rizzello, C.G. How Fermentation Affects the Antioxidant Properties of Cereals and Legumes. Foods 2019.

-      Doan, D.T.; Luu, D.P.; Nguyen, T.D.; Hoang Thi, B.; Pham Thi, H.M.; Do, H.N.; Luu, V.H.; Pham, T.D.; Than, V.T.; Pham Thi, H.H.; et al. “Isolation of Penicillium citrinum from Roots of Clerodendron cyrtophyllum and Application in Biosynthesis of Aglycone Isoflavones from Soybean Waste Fermentation”. Foods 2019

-      Sevgili, A.; Erkmen, O. Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora. Foods 2019.

-      Enbo Xu, Zhengzong Wu et al., “Calcium—lactate-induced enzymatic hydrolysis of extruded broken rice starch to improve Chinese rice wine fermentation and antioxidant capacity” Food Science and Technology, 2019.

-      Mauro Fisberg e Rachel Machado “History of yogurt and current patterns of consumption”, Nutrition

-      Assessment report on Echinacea angustifolia DC., radix– 27 Marzo 2012 EMA - Committee on Herbal Medicinal Products (HMPC)

-      Testo atlante di Fitoterapia – Max Wichtl Ed. Italiana 2002 per UTET a cura di Roberto Della Loggia, pp. 179-182

-      Clinical Overview – Echinacea- The ABC Clinical Guide to Herbs, pp. 85-96

-      R. Maffei Facino et al.; Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage – Planta Med; 61(1995)510

-      F. Firenzuoli, Fitoterapia. Guida all’uso delle piante medicinali. Edra Spa Editore.
-      WHO. Echinacea. In: WHO monographs on selected medicinal plants. Geneva: World Health Organization, 1999: 125–44.

-      Sachin A Shah et al. Evaluation of Echinacea for the prevention and treatment of the common cold: a meta-analysis, Lancet Infect Dis 2007

-      Michael Gallo, Pregnancy outcome following gestational exposure to Echinacea, American Medical Association, 2000.

-      Linda S. Kim, Immunological Activity of Larch Arabinogalactan and Echinacea: A Preliminary, Randomized, Double-blind, Placebo-controlled Trial, Altern Med Rev 2002;7(2):138-149

-      Matthias et al, Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations, Phytomedicine , 2007, Pages 587-590

-      Pleschka, S., et al. Anti-Viral Properties and Mode of Action of Standardized Echinacea Purpurea Extract against Highly Pathogenic Avian Influenza Virus (H5N1, H7N7) and Swine-Origin H1N1 (S-OIV). Virology Journal,(2009)

-      S M Sharma et al. Bactericidal and anti-inflammatory properties of a standardized Echinacea extract (Echinaforce): dual actions against respiratory bacteria, Phytomedicine, 2010

-      EMA/HMPC/557979/2013 Committee on Herbal Medicinal Products (HMPC) Assessment report on Echinacea purpurea (L.) Moench., herba recens24 November 2014

-      M. Jawad et al, Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial, Evidence-Based Complementary and Alternative Medicine, 2012

-      Saunders et al, Echinacea purpurea L. in children: safety, tolerability, compliance and clinical effectiveness in upper respiratory tract infections. Can J. Physiol. Pharmacol. 2007

-      Michael Gallo, Pregnancy outcome following gestational exposure to Echinacea, American Medical Association, 2000.

-      Roger A Burger, Anthony R.Torres et al., Echinacea-induced cytokine production by human macrophages, International Journal of Immunopharmacology, 1997

-      Matthias et al, Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations, Phytomedicine , 2007, Pages 587-590

-      M. Stimpel, Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infection and Immunity, 1984
-      Juerg Gertsch et al., Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways, FEBS let, 2004

-      Xiao-HuGan et al, Mechanism of activation of human peripheral blood NK cells at the single cell level by Echinacea water soluble extracts: recruitment of lymphocyte–target conjugates and killer cells and activation of programming for lysis, International Immunopharmacology, Volume 3, Issue 6, June 2003

-      Schulten, Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial. Arzneimittelforschung, 2001

-      Goel at al, Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther, 2004

-      Wendy Weber et al., Echinacea purpurea for Prevention of Upper Respiratory Tract Infections in Children. The Journal of Alternative and Complementary Medicine Vol. 11, No. 6 Original Paper, 2005

-      Brett J. West et al., “The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies”, 2018

-      Wang, M.Y.et al, “Antioxidant activity of noni juice in heavy smokers” Chem. Cent. J. 2009.
-      Wang, M.Y.; et al., “ Noni juice reduces lipid peroxidation–derived DNA adducts in heavy smokers”. Food Sci. Nutr. 2013.

-      Ma, D.L.; Jun, Z.; Jianhua, G. “The effect of Tahitian Noni Juice on antioxidation and immune function.”Chin. Med. Res. Clin. 2008, 6, 8–10.

-      Wang, M.Y.; Su, C. Cancer preventive effect of Morinda citrifolia (Noni). Ann. N. Y. Acad. Sci. 2001.
-      Wang, C.Y., Ng, C.C., Su, H., Tzeng, W.S., Shyu, Y.T., “Probiotic potential of noni juice fermented with lactic acid bacteria and bifidobacteria” Int. J. Food Sci. Nutr. 60 (Suppl. 6), 2009

-      David Morakinyo Sanni et al., “Xeronine structure and function: computational comparative mastery of its mystery”, In Silico Pharmacol. 2017
-      Palu AK, Kim AH, West BJ, Deng S, Jensen J, White L. The effects of Morindacitrifolia L. (noni) on the immune system: Its molecular mechanisms of action. Journal of Ethnopharmacology. 2008.
-      Amsterdam JD., et al., Rhodiola rosea L. as a putative botanical antidepressant, Phytomedicine, 2016

-      Singh, K. V. Peter, New Age Herbals, pp 71-113, Springer Nature Singapore, 2018

-      Chang PK., et al., Protective Effects of Rhodiola Crenulata Extract on Hypoxia-Induced Endothelial Damage via Regulation of AMPK and ERK Pathway, Int J Mol Sci, 2018

-      Ciumaşu-Rîmbu M., et al., Neuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposure, Rev Med Chir Soc Med Nat Iasi, 2012

-      Concerto C., et al., Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans, Complement Ther Med. 2018

-      Cropley M., et al., The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms, Phytother. Res, 2015

-      Edwards D., et al., Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study, Phytother Res, 2012

-      Huang LY., et al., Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells, Am J Chin Med. 2017

-      Jówko E., et al., Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men, J Sport Health Sci. 2018

-      Kaur P., et al., Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated processes, Biomed Pharmacother. 2017

-      Kwon YI., et al., Evaluation of Rhodiola crenulata and Rhodiola rosea for management of Type II diabetes and hypertension, Asia Pac J Clin Nutr 2006

-      Lee SY., et al., Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway, Phytomedicine, 2015

-      Noreen EE., et al., The effects of an acute dose of Rhodiola rosea on endurance exercise performance, J Strength Cond Res. 2013

-      Olsson EMG., et al., A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots of Rhodiola rosea in the Treatment of Subjects with Stress-Related Fatigue, Planta Med, 2009

-      Parisi A., et al., Effects of chronic rhodiola rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results, J Sports Med Phys Fitness, 2010

-      Sarris J., et al., Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence, CNS Drugs, 2013

-      Tao H., et al., Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study, Med Res Rev. 2019

-      Thu OK., et al., Effect of commercial Rhodiola rosea on CYP enzyme activity in humans, Eur J Clin Pharmacol. 2016

-      Wu YYX., et al., Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model, Food Chem Tox, 2019

-      Zhang H., et al., Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer, Drugs, 2012

-      Zhou Q., et al., Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function, Phytomedicine, 2018

-      Anup Sharma et al. Non-Pharmacological Treatments for ADHD in Youth. Adolesc Psychiatry (Hilversum). 2015

-      PDR, Physicians’ Desk Reference, CEC Editore, 2010

-      Bhutta ZA ey al. Prevention of diarrhea and pneumonia in children in developing countries. J Pediatr. 1999
-      Wapnir RA, Stiel et al. J Nutr, 1986
-      Stamatiadis et al. Inhibition of 5α-reductase activity in human skin by zinc and azelaic acid. British J Dermatology, 1988
-      Alan Leake at al. The effect of zinc on 5α-reduction of testosterone by the hyperplastic human prostate gland, Journal of Steroid Biochemistry 20(2):651-5, 1984

-      Brigitte Dreno et al. Multicenter Randomized Comparative Double-Blind Controlled Clinical Trial of the Safety and Efficacy of Zinc Gluconate versus Minocycline Hydrochloride in the Treatment of Inflammatory Acne vulgaris. Dermatology 2001;203:135–140

-      Maria Maares, Hajo Haase. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients 2020,

-      Ananda S. Prasad. Zinc in human health: effect of zinc on immune cells. M O L M E D 2 0 0 8
-      Luca Pecoraro et al. The potential role of zinc, magnesium and selenium against COVID-19: a pragmatic review, Child and Adolescent Obesity, 2021

GSE IMMUNOBIOTIC

GSE IMMUNOBIOTIC JUNIOR

-      Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002 Jun; 8(3):333-40

-      Cvetnić Z, Vladimir-Knezević S. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharm. 2004 Sep; 54(3):243-50

-      Zanotti Simões Dourado GK, de Abreu Ribeiro LC, Zeppone Carlos I, Borges César T. Orange Juice and Hesperidin Promote Differential Innate Immune Response in Macrophages ex vivo. Int J Vitam Nutr Res. 2013 Giugno; 83(3):162–7

-      Sharamon S, Baginski BJ. Le virtù terapeutiche dei semi di Pompelmo. Tecniche Nuove, Milano, 2004

-      Al-Ani WN, Tawfih NOM, Shehab EY: Antimicrobial activity of grapefruit seeds extracts (In vitro study). Al-Rafidain Dental Journal 2011, 11(2):341-345.

-      Joshi R, Kulkarni YA, Wairkar S. Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update. Life Sci. 2018; 215:43-56.

-      Xu H, Kulkarni KH, Singh R, et al. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009;6(6):1703-1715.

-      V. Verardo et al., “Bioactive Components in Fermented Foods and Food By-Products”, Foods 2020

-      Verni, M.; Verardo, V.; Rizzello, C.G. How Fermentation Affects the Antioxidant Properties of Cereals and Legumes. Foods 2019.

-      Doan, D.T.; Luu, D.P.; Nguyen, T.D.; Hoang Thi, B.; Pham Thi, H.M.; Do, H.N.; Luu, V.H.; Pham, T.D.; Than, V.T.; Pham Thi, H.H.; et al. “Isolation of Penicillium citrinum from Roots of Clerodendron cyrtophyllum and Application in Biosynthesis of Aglycone Isoflavones from Soybean Waste Fermentation”. Foods 2019

-      Sevgili, A.; Erkmen, O. Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora. Foods 2019.

-      Enbo Xu, Zhengzong Wu et al., “Calcium—lactate-induced enzymatic hydrolysis of extruded broken rice starch to improve Chinese rice wine fermentation and antioxidant capacity” Food Science and Technology, 2019.

-      Mauro Fisberg e Rachel Machado “History of yogurt and current patterns of consumption”, Nutrition

-      EMA/HMPC, “Assessment report on Uncaria tomentosa (Willd. ex Schult.) DC., cortex”, 2015
-      Mirtha Navarro ET AL., “Polyphenolic Composition and Antioxidant Activity of Uncaria tomentosa Commercial Bark Products”, Antioxidant, 2019
-      Y. Sheng et al., “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study”, Phytomedicine, 2001
-      Cristina Gonc. Et al, “Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity” Phytochemistry, 2005
-      PDR, Physicians’ Desk Reference, CEC Editore, 2010

-      Aleksandra Podgórska et al. Acne Vulgaris and Intake of Selected Dietary Nutrients—A Summary of Information, Healthcare 2021

-      Mark G Rubin et al. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids in Health and Disease, 2008

-      Youcef Mehdi et al. Selenium in the Environment, Metabolism and Involvement in Body Functions. Molecules, 2013

-      G Michaëlsson, L E Edqvist. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment . Acta Derm Venereol, 1984
-      Haidar Hamid Al-Anbari et al. Effects of silymarin, N-acetylcysteine and selenium in the treatment of papulopustular acne. Oxid Antioxid Med Sci. 2012
-      R. Juhaszn e Toth. The role of selenium in nutrition. A review. Acta Univ. Sapientiae, Alimentaria, 11 (2018)

-      David Benton. Selenium Intake, Mood and Other Aspects of Psychological Functioning. Nutritional Neuroscience, 2002 Vol. 5 (6), pp. 363–374

-      Scott, B.H. The Effect of Selenium Supplementation on the Mood of Chronic Fatigue Syndrome and Healthy Control Subjects, M. Sc Thesis, University of Canterbury (New Zealand, 1993).
-      M. Ferencik et al. Modulatory Effects of Selenium and Zinc on the Immune System. Folia Microbiol. 48 (3), 417–426 (2003)

-      Arash Moghaddam et al. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients 2020

-      PDR, Physicians’ Desk Reference, CEC Editore, 2010

-      Bhutta ZA ey al. Prevention of diarrhea and pneumonia in children in developing countries. J Pediatr. 1999
-      Wapnir RA, Stiel et al. J Nutr, 1986
-      Stamatiadis et al. Inhibition of 5α-reductase activity in human skin by zinc and azelaic acid. British J Dermatology, 1988

-      Alan Leake at al. The effect of zinc on 5α-reduction of testosterone by the hyperplastic human prostate gland, Journal of Steroid Biochemistry 20(2):651-5, 1984

-      Brigitte Dreno et al. Multicenter Randomized Comparative Double-Blind Controlled Clinical Trial of the Safety and Efficacy of Zinc Gluconate versus Minocycline Hydrochloride in the Treatment of Inflammatory Acne vulgaris. Dermatology 2001;203:135–140

-      Maria Maares, Hajo Haase. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients 2020,
-      Ananda S. Prasad. Zinc in human health: effect of zinc on immune cells. M O L M E D 2 0 0 8
-      M. FERENÍK, L. EBRINGER et al. Modulatory Effects of Selenium and Zinc on the Immune System, Folia Microbiol. 48 (3), 417–426 (2003)

-      Bakhtiari et al. A Comparison Between Serum Selenium Level in Febrile Children with or Without Seizure. Biological Trace Element Research (2021).

-      Barbara Kamer et al. Role of selenium and zinc in the pathogenesis of food allergy in infants and young children. Arch Med Sci 2012

-      Luca Pecoraro et al. The potential role of zinc, magnesium and selenium against COVID-19: a pragmatic review, Child and Adolescent Obesity, 2021

-      Shakeri A, et al. Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2016; 188:204-28

-      Miraj S, et al. Melissa officinalis L: a review study with an antioxidant prospective. J Evid Based Complementary Altern Med. 2017; 22:385-394

-      Mimica-Dukic N, et al. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J Agric Food Chem. 2004; 52:2485-9

-      Geuenich S, et al. Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology 2008; 5:27

-      Astani A, et al. Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro. Chemotherapy. 2012; 58:70-7

-      Chen SG, et al. Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Sci Rep. 2017; 7:12264

-      Martins EN, et al. Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice. Brain Res Bull. 2012; 87:74-9

-      Moacă EA, et al. A comparative study of Melissa officinalis lLeaves and stems ethanolic extracts in terms of antioxidant, cytotoxic, and antiproliferative potential. Evid Based Complement Alternat Med. 2018; 2018:7860456

-      Guginski G, et al. Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. Pharmacol Biochem Behav. 2009; 93:10-6

-      Hasanein P & Riahi H. Antinociceptive and antihyperglycemic effects of Melissa officinalis essential oil in an experimental model of diabetes. Med Princ Pract. 2015; 24:47-52

-      Sforcin JM, et al. Lemongrass effects on IL-1beta and IL-6 production by macrophages. Nat Prod Res. 2009; 23:1151-9

-      La Rocca V, et al. Geraniol Induces Antinociceptive Effect in Mice Evaluated in Behavioural and Electrophysiological Models. Basic Clin Pharmacol Toxicol. 2017; 120:22-29

-      Savino F, et al. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants. Phytother Res. 2005; 19:335-40

-      Müller SF & Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006; 13:383-7

-      Gromball J, et al. Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school children. Phytomedicine. 2014; 21: 1098-103

-      Kennedy DO, et al. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004; 66:607-13

-      Cases J, et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011; 4:211-218

-      Tavares-Silva C, et al. Homeopathic medicine of Melissa officinalis combined or not with Phytolacca decandra in the treatment of possible sleep bruxism in children: A crossover randomized triple-blinded controlled clinical trial. Phytomedicine. 2019; 58:152869

-      Haybar H, et al. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN. 2018; 26:47-52

-      Zeraatpishe A, et al. Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. Toxicol Ind Health. 2011; 27:205-12

-      Wölbling RH & Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine. 1994; 1:25-31

-      Karousou R, et al. "Mints", smells and traditional uses in Thessaloniki (Greece) and other Mediterranean countries. J Ethnopharmacol. 2007; 109:248-57

-      Anwar F, et al. Mentha: A genus rich in vital nutra-pharmaceuticals-A review. Phytother Res. 2019; 33:2548-2570

-      Mahboubi M. Mentha spicata as natural analgesia for treatment of pain in osteoarthritis patients. Complement Ther Clin Pract. 2017; 26:1-4

-      Petersen M & Simmonds MS. Rosmarinic acid. Phytochemistry. 2003; 62:121-5

-      Vejdani R, et al. The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study. Dig Dis Sci. 2006; 51:1501-7

-      Connelly AE, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food. 2014; 17:1361-7

-      Herrlinger KA, et al. Spearmint extract improves working memory in men and women with age-associated memory impairment. J Altern Complement Med. 2018; 24:37-47

-      Lasrado A, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol. 2017; 86:167-176

-      Falcone PH, et al. The attention-enhancing effects of spearmint extract supplementation in healthy men and women: a randomized, double-blind, placebo-controlled, parallel trial. Nutr Res. 2019; 64:24-38

-      Shahbazi Y. Chemical composition and In Vitro antibacterial activity of Mentha spicata essential oil against common food-borne pathogenic bacteria. J Pathog. 2015; 2015:916305

-      Snoussi M, et al. Mentha spicata essential oil: chemical composition, antioxidant and antibacterial activities against planktonic and biofilm cultures of Vibrio spp. Strains. Molecules. 2015; 20:14402-24

-      Wiwattanarattanabut K, et al. In vitro anti-cariogenic plaque effects of essential oils extracted from culinary herbs. J Clin Diagn Res. 2017; 11:DC30-DC35

-      Stringaro A, et al. Antioxidant, antifungal, antibiofilm, and cytotoxic activities of Mentha spp. essential oils. Medicines. 2018; 5(4). pii: E112.

-      Hu Z, et al. Antioxidant effect of aromatic volatiles emitted by Lavandula dentata, Mentha spicata, and M. piperita on mouse subjected to low oxygen condition. Biosci Biotechnol Biochem. 2017; 81:2386-2395

-      Ben Saad A, et al. Protective effects of Mentha spicata against nicotine-induced toxicity in liver and erythrocytes of Wistar rats. Appl Physiol Nutr Metab. 2018; 43:77-83

-      Mogosan C, et al. a comparative analysis of the chemical composition, anti-inflammatory, and antinociceptive effects of the essential oils from three species of Mentha cultivated in Romania. Molecules. 2017; 22(2). pii: E263

-      Direito R, et al. Reduction of inflammation and colon injury by a spearmint phenolic extract in experimental bowel disease in mice. Medicines 2019;6(2). pii: E65

-      Caro DC, et al. Pharmacological evaluation of Mentha spicata l. and Plantago major l., medicinal plants used to treat anxiety and insomnia in colombian caribbean coast. Evid Based Complement Alternat Med. 2018; 2018:5921514

-      Sadeghi Ataabadi M, et al. Role of essential oil of Mentha Spicata (Spearmint) in addressing reverse hormonal and folliculogenesis disturbances in a Polycystic Ovarian Syndrome in a rat model. Adv Pharm Bull. 2017 Dec;7(4):651-654

-      Naomi Osakabe et al., Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism, BioFactors, Volume 21, Issue 1-4, pages 127–131, 2004.

-      J. Stansbury et al., Rosmarinic acid as a novel agent in the treatment of allergies and asthma. Journal of Restorative Medicine 2014.

-      J. Lee et al., Rosmarinic acid as a downstream inhibitor of IKK-b in TNF-a-induced upregulation of CCL11 and CCR3. British Journal of Pharmacology (2006)

-      Katsunari lppoUSHI et al., Evaluation of Inhibitory Effects of Vegetables and Herbs on Hyaluronidase and ldentification of Rosmarinic Acid as a Hyaluronidase Inhibitor in Lemon Balm (Melissa officinalis L.), FoodSci. Technol Res., 6 ( I). 74-77. 2000

-      Baba S, et al. Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. Eur J Nutr. 2005; 44:1-9

-      Noguchi-Shinohara M, et al. Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. PLoS One. 2015.

-      Z. Krajcovicova et al., Bioactivity and potential health benefits of rosmarinic acid. University Review, 2013.

-      Sang-Bum Kim et al., Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases, Biomed Pharmacotherapy, 2019.

GSE INFLUBIOTIC

- Krawitz C, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011; 11:16.

- Zakay-Rones Z, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. Winter 1995; 1:361-9

- Roschek B Jr, et al. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009; 70:1255-61

- Swaminathan K, et al. Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry. Anal Bioanal Chem. 2013; 405:6563-72

- Kong F-K, et al. Pilot clinical study on a proprietary elderberry extract: eficacy in addressing infuenza symptoms. J Pharmacol Pharmacokinet 2009; 5:32–43

- Tiralongo E, et al. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016; 8:182

- Hawkins J, et al. Black Elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019; 42:361-365

-      Mlynarczyk K, et al. The Content of Selected Minerals, Bioactive Compounds, and the Antioxidant Properties of the Flowers and Fruit of Selected Cultivars and Wildly Growing Plants of Sambucus nigra L. Molecules 2020; 25:876
-      Fang J. Bioavailability of anthocyanins. Drug Metab Rev. 2014; 46:508-20
-      Passamonti S, et al. The interaction of anthocyanins with bilitranslocase. Biochem Biophys Res Commun. 2002; 296:631-6

- Czank C, et al. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A (13)C-tracer study. Am J Clin Nutr 2013; 97:995-1003

- Moyo M & Van Staden J. Medicinal properties and conservation of Pelargonium sidoides DC. J Ethnopharmacol. 2014; 152:243-55

- Michaelis M, et al. Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine 2011; 18:384-386

- Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. Phytomedicine 2007; 14:9-17

- Conrad A, et al. Extract of Pelargonium sidoides (EPs 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. Phytomedicine. 2007; 14 Suppl 6:52-9.

- Thäle C, et al. Anti-infective mode of action of EPs 7630 at the molecular level. Planta Med. 2008; 74:675-81

- Thale C, et al. Anti-infective activities of Pelargonium sidoides (EPS 7630): effects of induced NO production on Leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assay. Planta Med. 2011; 77:718-25

- Roth M, et al. Up-Regulated Vitamin D Receptor by Pelargonium sidoides Extract EPs ® 7630 Contributes to Rhinovirus Defense in Bronchial Epithelial Cells. Pharmaceuticals (Basel). 2021; 14:172

- Matthys H, et al. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine 2003; 10:7-17

- Lizogub VG, et al. Efficacy of Pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore 2007; 3:573-584

- Bereznoy VV, et al. Efficacy of extract of Pelargonium sidoides in children with acute non group A beta-hemolytic Streptococcus tonsillopharyngitis: a randomized, double blind, placebo-controlled trial. Altern Ther Health Med 2003; 9:68-79

- Peric A, et al. Effects of Pelargonium sidoides extract on chemokine levels in nasal secretions of patients with non-purulent acute rhinosinusitis. J Drug Assess. 2020; 9:145-150

- European Medicine Agency. Assessment report on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. EMA/HMPC/444251/2015. 05 June 2018

- European Medicine Agency. European Union herbal monograph on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. EMA/HMPC/444244/2015. 05 June 2018

- Roth M, et al. Up-Regulated Vitamin D Receptor by Pelargonium sidoides Extract EPs® 7630 Contributes to Rhinovirus Defense in Bronchial Epithelial Cells. Pharmaceuticals (Basel). 2021 Feb 22;14(2):172.

- D’Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015; 106:256-71

- Ganesan S, et al. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 2012; 94:258-71

- Wu W, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015; 8:6

- Mehrbod P, et al. Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Biomolecules 2020; 11:10

- Jo S, et al. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020; 35:145-151

- Khaerunnisa S, et al. Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Preprints 2020, 2020030226

- Smith M, et al. Repurposing therapeutics for COVID-19: supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. Biological and Medicinal Chemistry 2020

- Rice-evans CA, et al. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 1995; 22:375-83

- Meyer AS, et al. Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation. Food Chemistry 1998; 61: 71-75

- Xu D, et al. Antioxidant activities of quercetin and its complexes for medicinal application. Molecules 2019; 24: 1123

- Riva A, et al. Quercetin phytosome in triathlon athletes: a pilot registry study. Minerva Med. 2018; 109:285-289

- Mrityunjaya M, et al. Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19. Front Immunol. 2020; 11:570122.

- Li Y, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016; 8:167

- Mlcek, J. Quercetin and its anti-allergic immune response. Molecules 2016; 21:623

- Fortunato LR, et al. Quercetin: a flavonoid with the potential to treat asthma. Brazilian Journal of Pharmaceutical Sciences 2012; 48: 589-599

- Massi A, et al. Research progress in the modification of quercetin leading to anticancer agents. Molecules 2017; 22: E1270

- Riva A, et al. Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. Eur J Drug Metab Pharmacokinet. 2019; 44:169-177

- Rastogi H & Jana S. Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities. Phytother. Res. 2014; 28, 1873-1878

- Mohos V, et al. Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters. Nutrients 2020; 12: 2306

- European Medicine Agency. Assessment report on Hedera helix L., folium. EMA/HMPC/325715/2017; 21 November 2017

- Cioacá C, Margineanu C, Cucu V. The saponins of Hedera helix with antibacterial activity. Pharmazie 1978; 33:609-10

- Moulin-Traffort J, et al. Study of the action of alpha-hederin on the ultrastructure of Candida albicans. Mycoses 1998; 41:411-6

- Rao GS, Sinsheimer JE. Antiviral activity of triterpenoid saponins containing acylated beta-amyrin aglycones. J Pharm Sci 1974; 63:471-3

- Hong E-H, Song J-H, Shim A, et al. Coadministration of Hedera helix L. extract enabled mice to overcome insufficient protection against influenza A/PR/8 virus infection under suboptimal treatment with oseltamivir. PLoS ONE 2015; 10:e0131089

- Fazio S, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009; 16:17-24

- Kemmerich B, et al. Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled clinical trial. Arzneimittelforschung 2006; 56:652-60

- Bolbot Y, et al. Comparing the efficacy and safety of high-concentrate (5-7.5:1) ivy leaves extract and acetylcysteine for treatment of children with acute bronchitis,” Liky Ukrainy 2004; 11 (Ukrainian)

- Holzinger F and Chenot JF. Systematic Review of Clinical Trials Assessing the Effectiveness of Ivy Leaf (Hedera Helix) for Acute Upper Respiratory Tract Infections. Evid Based Complement Alternat Med. 2011; 2011: 382789

- Lang C, et al. A Valuable Option for the Treatment of Respiratory Diseases: Review on the Clinical Evidence of the Ivy Leaves Dry Extract EA 575®. Planta Med. 2015; 81:968-74

- Zeil S, Schwanebeck U, Vogelberg C. Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma. Phytomedicine 2014; 21: 1216–1220

- Hofmann D, et al. Efficacy of dry extract of ivy leaves in children with bronchial asthma-a review of randomized controlled trials. Phytomedicine. 2003; 10:213-20

- Sieben A, et al. Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors. Biochemistry. 2009; 48:3477-82

- Wolf A, et al. Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle. Phytomedicine 2011; 18:214-8

- Greunke C, et al. A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells. Pulmonary Pharmacology & Therapeutics 2015; 31:e92e98

- European Medicine Agency. European Union herbal monograph on Hedera helix L., folium. EMA/HMPC/325716/2017; 21 November 2017

- Cvetnić Z, Vladimir-Knezević S. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharm. 2004 Sep; 54(3):243-50

- Zanotti Simões Dourado GK, de Abreu Ribeiro LC, Zeppone Carlos I, Borges César T. Orange Juice and Hesperidin Promote Differential Innate Immune Response in Macrophages ex vivo. Int J Vitam Nutr Res. 2013; 83:162–7

- Sharamon S, Baginski BJ. Le virtù terapeutiche dei semi di Pompelmo. Tecniche Nuove, Milano, 2004

- Al-Ani WN, Tawfih NOM, Shehab EY: Antimicrobial activity of grapefruit seeds extracts (In vitro study). Al-Rafidain Dental Journal 2011; 11:341-345.
- Parmar NS, Parmar S. Anti-ulcer potential of flavonoids. Indian J Physiol Pharmacol. 1998 Jul; 42:343-51. Review

- Joshi R, Kulkarni YA, Wairkar S. Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update. Life Sci. 2018; 215:43-56.

- Xu H, Kulkarni KH, Singh R, et al. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009; 6:1703-1715.

- PDR, Physicians’ Desk Reference, CEC Editore, 2010

- Wapnir RA & Stiel L. Zinc intestinal absorption in rats: specificity of amino acids as ligands. Journal of Nutrition. 1986; 116:2171–2179.
- Maria Maares, Hajo Haase. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients 2020.

- IV Revisione dei Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana (LARN). Società Italiana di Nutrizione Umana (SINU). 2014

- Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017 Nov 25;9(12):1286.

- Skrajnowska D, Bobrowska-Korczak B. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients. 2019 Sep 22;11(10):2273.

- Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998 Aug;68(2 Suppl):447S-463S.

- Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol. 1976 Apr;18(1):298-306.

- Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019 Jul 1;10(4):696-710.
- Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S, Black RE: Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004; 363: 1683–1688.

- Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94.

- Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013 Jun 18;(6):CD001364. Update in: Cochrane Database Syst Rev. 2015;(4):CD001364.

- Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK, Fernández-Larrea JB. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem. 2014 Aug 13;62(32):8085-93.

- Clergeaud G, Dabbagh-Bazarbachi H, Ortiz M, Fernández-Larrea JB, O'Sullivan CK. A simple liposome assay for the screening of zinc ionophore activity of polyphenols. Food Chem. 2016 Apr 15;197(Pt A):916-23.

- Maares M, Haase H. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients. 2020 Mar 13;12(3):762.

- Wapnir RA, Stiel L. Zinc intestinal absorption in rats: Specificity of amino acids as ligands. J Nutr . 1986; 116:2171-2179.

- Göring H. Vitamin D in Nature: A Product of Synthesis and/or Degradation of Cell Membrane Components. Biochemistry (Mosc). 2018 Nov;83(11):1350-1357.

- IV Revisione dei Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana (LARN). Società Italiana di Nutrizione Umana (SINU). 2014

- European Food Safety Authority (EFSA) - Panel on Dietetic Products, Nutrition and Allergies (NDA). Dietary reference values for vitamin D. EFSA Journal published by John Wiley and Sons Ltd on behalf. EFSA-Q-2011-01230. 2016; 14(10):4547.

- Borel P, Caillaud D, Cano NJ. Vitamin D bioavailability: state of the art. Crit Rev Food Sci Nutr. 2015;55(9):1193-205.

- Aranow C. Vitamin D and the immune system. J Investig Med. 2011 Aug;59(6):881-6.

- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 May;91(5):1255-60.

- Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015 May 29;7(6):4240-70.

GSE INFLUBIOTIC JUNIOR

- Roschek B Jr, et al. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009; 70:1255-61

- Swaminathan K, et al. Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry. Anal Bioanal Chem. 2013; 405:6563-72

- Kong F-K, et al. Pilot clinical study on a proprietary elderberry extract: eficacy in addressing infuenza symptoms. J Pharmacol Pharmacokinet 2009; 5:32–43

- Tiralongo E, et al. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016; 8:182

- Fang J. Bioavailability of anthocyanins. Drug Metab Rev. 2014; 46:508-20

- Passamonti S, et al. The interaction of anthocyanins with bilitranslocase. Biochem Biophys Res Commun. 2002; 296:631-6

- Czank C, et al. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A (13)C-tracer study. Am J Clin Nutr 2013; 97:995-1003

- WHO Monograph on Selected Medicinal Plants, Vol. 1,”Radix astragali”, 1999

- Astragalus membranaceus Monograph, Alternative Medicine Review, 2003

- Chang HM. Pharmacology and Applications of Chinese Materia Medica. (Volume II). World Scientific Publishing. July 1987.

- Zhao XZ. [Effects of Astragalus membranaceus and Tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Nov;12(11):669-71, 645.

- Weng XS. [Treatment of leucopenia with pure Astragalus preparation--an analysis of 115 leucopenic cases]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):462-4.

- Yoshida Y, Wang MQ, Liu JN, Shan BE, Yamashita U. Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol. 1997 Jul;19(7):359-70.

- Institute of Basic Medical Science, The Chinese Academy of MEdical Science. Immunity parameters and blood cAMP changes in normal persons after ingestion of Radix Astragali. Chung hua i huesh t’sa chih. 1979. 59:31-34.

- Keith I. Block and Mark N. Mead, “Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review” Integr Cancer Ther 2003 2: 247
- Zou C, Su G, Wu Y, Lu F, Mao W, Liu X. Astragalus in the prevention of upper respiratory tract infection in children with nephrotic syndrome: evidence-based clinical practice. Evid Based Complement Alternat Med. 2013;2013:352130.

- Cho WC, Leung KN. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol. 2007 Aug 15;113(1):132-41.

- Chu C, Qi L, Liu E, Li B, Gao W, Li P. Radix Astragali (Astragalus): Latest Advancements and Trends in Chemistry, Analysis, Pharmacology and Pharmacokinetics. Current Organic Chemistry. 2010. 14:1792-1807.

- Guo Z, Lou Y, Kong M, Luo Q, Liu Z, Wu J. A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine. Int J Mol Sci. 2019;20(6):1463.

- D’Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015; 106:256-71

- Ganesan S, et al. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 2012; 94:258-71

- Wu W, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015; 8:6

- Mehrbod P, et al. Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Biomolecules 2020; 11:10
- Jo S, et al. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020; 35:145-151

- Khaerunnisa S, et al. Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Preprints 2020, 2020030226

- Rice-evans CA, et al. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 1995; 22:375-83
- Meyer AS, et al. Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation. Food Chemistry 1998; 61: 71-75