Our purpose is not to hinder the physiological processes of the organism. Ours is a holistic approach. An approach that encourages the ristoring of the physical balance, by facing the causes as efficiently as possible and by ensuring a fast relief of all the symptoms.
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Osteo-articular and muscular problems, characterised by more or less intense pain, rigidity and difficulty of movement, represent the most frequent reason for patients consulting their family doctor. In fact, about 30 – 40% of complaints regard acute pain, mostly involving the back, neck, shoulders, and can be the consequence of a trauma or muscle fatigue (often related to a sports or work activity or resulting from bad posture).
It is estimated that 5,5 million people in Italy are affected by chronic-developing osteo-articular and/or muscular diseases. In both cases a high tendency to use anti-inflammatory synthetic medicines has been recorded, involving heavy consequences for patients’ health: the longer the period of intake, the more disastrous the negative impact. Here follows a brief overview of the most common muscular and osteo-articular pathologies.
|PROBLEMS||THE MOST COMMON||SYMPTOMS||DURATION|
|MUSCLES, LIMBS, TENDINS||
||Normally short to medium course of illness.
Once the acute phase has been overcome, chronicity can arise if causes and predisposing factors are eliminated.
||Normally long course of illness.
In most cases, these pathologies lead to chronicity and functional alternations.
Among the painful pathologies affecting the musculoskeletal system, characterized by persistent, invalidating pain: lumbar and sciatic pain and carpal tunnel syndrome, extremely painful disorders due to inflammation of the nerves (sciatic nerve and median nerve, respectively).
Tendons are fibrous bundles connecting muscles to the bones; their function is to enable bones to move following muscle contraction.
Tendinitis occurs when an inflammatory process involves one or more of the almost 300 tendons present in our organism (healthy tendins are rarely affected by acute inflammations from overwork and in such case it is the muscles or bones to suffer harm). This type of inflammation is caused by overfatigue, microtraumas, and continuous micro-stresses experienced by tendons and that harm the fibres they are made of.
Even if tissues tend to restore damaged parts, the integrity and elasticity of the original tendon is no longer restored and is therefore less resistant to continuous motor stimuli, particularly if blood flow is scarce. Causes of tendinitis can be: heightened frequency and intensity of training, overtraining, inadequate clothing and footwear, running on uneven or particularly hard terrain, or slippery or too soft terrains such as sand, incorrect technical execution of an exercise, imbalance between muscular strength and tendon resistance (frequent in those taking anabolic steroids), local injections of corticosteroids, lack of general and specific warm-up, resuming training too quickly after accidents, postural defects.
Systemic pathologies, however, can also be involved in the root causes for this disorder: for instance, rheumatoid arthritis, lupus erythematosus, gout, hypercholesterolemia or renal failure; congenital factors such as dysmetria of the limbs, defects regarding axiality (anomalies in physiological curves of the rachis, valgus deformity or knee varus, articular conflicts, etc.), ageing (around 30-35, tendons lose tonicity and vascularization), as well as hormonal variations.
The typical symptom signalling tendinitis is acute pain close to the anatomical area where the inflamed tendon is located, particularly following a movement involving excessive strain. If the tendon suffers a lesion to the point that it is completely fractured, swelling and bruising can appear. Morever, swelling is also possible if the inflammation extends to the tendon sheaths.
Anatomical districts most affected by tendinitis are the shoulders, elbows (epicondylitis or “tennis elbow”), wrists, hands, knees, ankles (Achilles tendon) and feet.
Epicondylitis or “tennis elbow” is a form of degenerative-inflammatory tendinitis affecting the epicondyle muscles (extensor muscles of the forearm), inserted in the elbow bone (epicondyle). It triggers as a result of repeated and intense movements typical of tennis players (but also relevant to golf, baseball, fencing and swimming, though more rarely in the case of swimming in particular), of workers who put too much strain on this specific joint (bricklayers, painters, etc.) but also due to physiological wear and tear: as a matter of fact, it does not appear before the age of 35. Symptoms are localized, very intense pain and weakness also in lifting small objects.
Treatment of tendinitis with conventional medicine
In case of tendinitis, conventional medicine resorts to anti-inflammatory medicines, administered in the form of topical applications (creams, gel, bandages soaked in a farmacological solution), as well as tablets, granulated products and even local injections in the most serious cases. Even though useful in providing relief from pain, anti-inflammatory medicines are, however, responsible for a long series of secondary effects, all the more serious according to the length of intake period.
Such side effects are essentially linked to the fact that the anti-inflammatory activity is carried out owing to a sole active principle which, not being selective, in addition to promoting the primary pharmacological activity (by reducing inflammation and pain), ends up altering several physiological mechanisms, leading to countless secondary activities. Among these medicines it is possible to identify two big groups: steroidal anti-inflammatories (cortisone-based medicines) and non steroidal anti-inflammatories, better known as “NSAIMs” (an acronym standing for Nonsteroidal Anti-inflammatory Medicines).
Among side-effects of cortisone-based medicines, which are very strong anti-inflammatories with immunosuppresant activities: in low dosages, glaucoma, intracranial hypertension, bowel perforation, gastric ulcer, gastric hemorrhage; at medium dosages: myopathy, increased blood pressure, diabetes, cataract; at high dosages, hyperglycemia, water retention, weight gain, growth retardation, osteoporosis, gastric ulcer and reduced immune defenses. Alternatively, patients resort to non steroidal anti-inflammatory medicines (NSAIMs, an acronym standing for Nonsteroidal Anti-inflammatory Medicines), for instance those containing active principles such as acetyl salicylic acid, ketoprofen, ibuprofen, diclofenac, nimesulide, etc., widely recommended medicines that act by inhibiting synthesis of chemical mediators called “prostaglandins”: such action is at the origin of both pharmacological activity as well as of numerous side-effects.
To comprehend just how this is possible it must be borne in mind that prostaglandins carry out multiple organic functions: there are, in fact, “bad” prostaglandins (though it is not technically correct to call them this way) as they cause the insurgence of inflammation, hyperalgesia, fever; but there are also “good” prostaglandins, carrying out multiple physiological activities: they promote protection of the stomach from gastric juices, they regulate renal blood flow, uterine contractions, platelet activity, etc.
That being said, it is clear that use of so-called NSAIMs, often turning into an “abuse” given their being easy to retrieve, is inevitably connected to several side-effects. Examples thereof are: inhibition of gastric protection, with consequences ranging from simple irritations to lesions, ulcera and gastrointestinal hemorrhage, inhibition of platelet aggregation, renal ischaemia, generic nephropathy and renal failure, etc.
This is why it is important to have available a valid, natural alternative, capable of providing relief in case of painful symptoms and rigidity connected to the problem of tendinitis, while being totally free from side-effects.
Nature can help you in case of tendinitis
A natural and effective approach
Nature can finally offer great help, thanks to the use of an exclusive formulation based on a selection of plant ingredients with marked anti-inflammatory properties, in order to contribute, day by day, to soothe inflammations, pain and rigidity characterizing the problem of tendinitis. All this without resorting to synthetic anti-inflammatory medicines, or at least limiting their quantity and number of intakes.
First and foremost among this is certainly BIOSTERINE®, a unique and innovative phytocompound, consisting in 80% extract of Ocimum sanctium (Holy Basil) and 20% of Salvia Officinalis, characterized by very high titration in Rosmarinic Acid (40%), obtained through a particular extraction process that has been developed and patented by Prodeco Pharma.
BIOSTERINE® and tendinitis
BIOSTERINE® not only combines the recognised anti-inflammatory properties of phytocomplexes belonging to Holy Basil and Salvia Officinalis, but actually amplifies and reinforces them, thanks to the high concentration of Rosmarinic Acid. In fact, numerous studies have confirmed the extraordinary properties of Rosmarinic Acid as an anti-inflammatory, investigating its potential mechanisms of action.
Rosmarinic Acid has the ability to inhibit inflammatory processes linked to the “complement system” (this is, in fact, a component of the immune system involved in the inflammatory process); besides this mechanism of action, considered to be mainly responsible for the anti-inflammatory action of Rosmarinic acid, it also acts by regulating cyclooxygenase, modulating the synthesis of inflammatory prostaglandins (in fact, it has been pointed out that Rosmarinic acid contained in Ocimum sanctum exerts a 58% inhibiting activity on cyclooxygenase).
The anti-inflammatory efficacy of Ocimum sanctium extracts has turned out to be comparable with that of ibuprofen, of naproxen and of acetylsalicylic acid, yet without causing any side effects whatsoever: presence in the phytocomplex of other active constituents, in fact, enables the harmonization and modulation of the inflammatory action, without the typical harmful effects reported on synthetic medicines.
This discovery confirms traditionally used Ocimum sanctum as a safe, reliable and effective anti-inflammatory. The action of rosmarinic acid is also exerted through inhibition of hyaluronidase, an enzyme responsible for the degradation of hyaluronic acid, essential for the integrity of connective tissues, in particular cartilages. These properties in particular confer rosmarinic acid with a protective role of tissues, mostly joint tissues, and combines well with its anti-inflammatory substances.
Due to the above-mentioned considerations, BIOSTERINE® in assocation with specific plant extracts therefore represents the cornerstone of
a natural approach to eliminate inflammation and pain, day by day, alleviating typical symptoms connected to the problem of tendinitis, yet causing any side-effects.
Nature can help you with…
BIOSTERINE®: as already highlighted, with its powerful health properties as an anti-inflammatory, BIOSTERINE® represents the starting point of our approach. Taken systemically, BIOSTERINE® exerts a marked anti-inflammatory action and reduces phlogosis of tissues affected. Its association with other specific, natural principles, make it possible to reach even more remarkable results.
Boswellia serrata: Boswellia extract possesses recognised anti-inflammatory properties and is particularly effective in painful pathologies affecting the musculo-skeletal apparatus. Its activity is attributable to the presence, in its phytocomplex, of particular compounds called boswellic acids. Numerous clinical studies have confirmed its efficacy, comparable to synthetic medicines, yet without causing any side-effects whatsoever.
The idea of including in the formulation both the dry extract with high titration in boswellic acids (75%), as well as the powder of the whole plant, has proven to be a successful one. In fact, this association enables to ensure, on the one hand, adequate supply of the “nobler” forms of active constituents (boswellic acids), for unquestionable efficacy; on the other it makes it possible to obtain the presence of the entire phytocomplex, for a synergistic and, at the same time, “smoother” effect on the organism, thereby ensuring that the product will be totally free from side-effects, also in the long run.
Turmeric: turmeric is used in phytotherapy for the treatment of several pathologies involving inflammations, including ostheoarthritis. Its anti-inflammatory action is attributable to the presence of particular substances called curcuminoids. Research has pointed out that the efficacy of turmeric extract is linked to its activity on several physiological mechanisms involved in the inflammatory process.
Turmeric therefore acts on the inflammation with a 360° mechanism, without causing any side-effect. Some of the fundamental mechanisms involved are as follows:
- a) inhibition of cyclooxygenase-2 and lipoxygenase enzymes, with a resulting reduced production of prostaglandins and other inflammatory chemical mediators;
- b) inhibition of the release of numerous pro-inflammatory cytokines and interleukins;
- c) inhibition of the production of cell adhesion molecules involved in the early phase of the inflammatory cascade
- d) inhibition of collagen degradation. The idea of including in the formulation both the dry extract, with high titration in curcuminoids (95%), as well as the powder of the entire plant has been a successful one: in fact, this association ensures maximum efficacy and lack of any side-effect whatsoever.
Hyaluronic Acid: its physiological function is to maintain the right level of hydration in connective tissues. It moreover acts as a cementing substance and as a kind of shock absorbing molecule, as well as being an efficient lubricant (synovial fluid/joints), preventing tissue damage. Its function is therefore fundamental to ensure good health and functionality of skeletal tissue and of the joints.
For this reason, Hyaluronic Acid has been used since it was first discovered to treat joint disorders. Besides the excellent results obtained following its use in intra-articular infiltrations, it has recently been studied to verify its efficacy for oral intake.
Regarding the formulation, Hyaluronic Acid is therefore used in association with Biosterine®, Boswellia and Turmeric, to complete the anti-inflammatory activity of the product. Another activity of Hyaluronic acid has recently been identified, making it particularly useful within the formulation: as a carrier of active molecules to increase bioavailability, once ingested and hydrated, Hyaluronic Acid forms a bioadhesive matrix bringing the active constituents into the solution and promoting their gradual release, saturating the mucosa and increasing contact time between active constituents and the intestinal mucosa itself.
It therefore ensures complete absorption of all constituents present in the phytocomplexes included (Biosterine®, Boswellia e Curcuma), optimizing their bioavailability and enhancing their efficacy.
The ideal form of intake of such plant ingredients is represented by swallowable tablets.
Nutritional lifestyle adopted has a significant impact on all muscular-skeletal inflammatory problems. Even though triggered off by different factors, often of traumatic nature, tendinitis is no exception. Eliminating, or at least reducing foodstuffs that accentuate the chronic inflammatory state of the organism can lead to remarkable benefits. In fact, certain foodstuffs act on our organism with a “pro-inflammatory” mechanism, contributing not only to trigger but to aggravate the painful-inflammatory symptoms characterizing such disorders.
Primarily responsible in this sense are foodstuffs of animal origin, with the exception of fish (which, on the contrary, being rich in polyunsaturated omega-3 fatty acids, exerts an anti-inflammatory action); meat (in particular red meat) and eggs, instead are rich in arachidonic acid, a precurosor of numerous inflammatory mediators which are produced, in the so-called “inflammatory cascade”, by the activity of cyclo-oxygenase and lipo-oxygenase enzymes.
However, the foodstuff mostly responsible for the insurgence of many inflammatory diseases, whether chronic or acute, is undoubtedly milk, together with all its derivatives. It is now certain that milk favours the increase of intestinal permeability and the introduction in the bloodstream of proteins – particularly casein, which trigger in the organism an immune stimulation, causing sensitization and a defensive, inflammatory response.
There is countless clinical evidence, as highlighted, for instance, in the book “Il mal di latte” (Milk sick) by Lorenzo Acerra (Marco ed.), mentioning cases in which arthritic patients, or subjects suffering from other kinds of muscular-skeletal problems, have improved their condition following the adoption of a diet that eliminated milk and dairy products; by contrast, reintroducing milk has led to the reappearance of symptoms.
In a natural approach aimed at solving osteo-articular and/or muscular problems, it is impossible not to recommend eliminating milk and its derivatives from the diet, as well as reducing consumption of animal proteins.
As a matter of fact, it is important to always remember that it is only by adopting a correct diet that the course of an illness can be changed, reducing the intensity and number of physical ailments present, extending periods of well-being and reducing relapse phases .
In brief, the following dietary programme is recommended:
FOODS TO AVOID
- Simple sugars (white sugar, glucose, sucrose, fructose, maltose, sorbitol, mannitol, lactose, galactose, maple juice, agave juice, honey, molasses)
- Milk and dairy products
- Packaged, preserved, refined food and drinks
- Foods to which you are intolerant or allergic
- Red meat
FOODS TO CONSUME WITH CAUTION
- Refined cereals (white bread, pasta and glazed rice)
- Whole cane sugar (only if necessary)
- White meat and eggs (organic)
- Foods rich in fibres (preferably seasonal vegetables and legumes)
- Seasonal fruit
- Whole grain cereals and pasta (kamut, spelt, rye, oats, etc.)
- Oleaginous seeds (nuts, almonds, sesame, sunflower)
- Linseed and olive oil from first cold pressing
Drink at least two litres of water daily, at ambient temperature and away from meals, choosing water with fixed residue levels below 50 mg/L and with pH lying between 6 and 7.