A natural and effective approach
In order to counter, day by day, inflammation, pain and rigidity characterizing the problem of arthrosis, thereby avoiding to have to resort to synthetic anti-inflammatory medicines, or at least limit the quantity of their intake, nature can finally be of valuable help, thanks to an exclusive formulation based on a selection of plant ingredients with markedly anti-inflammatory properties.
First and foremost among these is BIOSTERINE®, a unique and innovative phytocompound, consisting in 80% Ocimum sanctum (Holy Basil) extract and 20% Salvia officinalis extract, characterized by an extremely high titration in Rosmarinic Acid (40%), obtained through a particular extraction process developed by Prodeco Pharma.
BIOSTERINE® and arthrosis
BIOSTERINE® not only combines the recognized, anti-inflammatory properties of phytocomplexes contained in Holy Basil and Salvia Officinalis, but actually amplifies and reinforces them, thanks to the high concentration of Rosmarinic Acid. Numerous studies have, in fact, confirmed the extraordinary properties of Rosmarinic Acid as an anti-inflammatory, investigating its potential mechanisms of action.
Rosmarinic Acid’s ability to inhibit inflammatory processes linked to the “complement system” (part of the immune system involved in the inflammatory process) is well-known; besides this specific mechanism of action, considered to be primarily responsible for the anti-inflammatory action of Rosmarinic Acid, it also acts by regulating cyclooxygenase, modulating the synthesis of inflammatory prostaglandins (it has been pointed out the Rosmarinic acid contained in Ocimum sanctum exerts a 58% inhibiting action on cyclooxygenase).
The inflammatory efficacy of Ocimum sanctum extracts has turned out to be comparable with that of ibuprofen, of naproxen and of acetylsalicylic acid, yet without any side effects: the presence, in the phytocomplex, of other active constituents, in fact, enables the harmonization and modulation of the inflammatory action, with the typical harmful effects reported on synthetic medicines. This discovery confirms traditionally used Ocimum sanctum as a safe, reliable and effective anti-inflammatory.
The action of rosmarinic acid is also exerted through inhibition of hyaluronidase, an enzyme that is responsible for the degradation of hyaluronic acid, essential for the integrity of connective tissues, in particular cartilages. These properties in particular confer rosmarinic acid with a protective role on tissues, mostly joint tissues, and combines well with its anti-inflammatory properties.
Due to the above-mentioned considerations, in association with specific plant extracts, BIOSTERINE® therefore represents the cornerstone of
a natural approach to eliminate inflammation and pain, day by day, alleviating typical symptoms related to arthrosis, yet without any side-effects, even when taken for long periods of time.
Nature can help you with…
BIOSTERINE®: as already highlighted, with its powerful health properties as an anti-inflammatory, BIOSTERINE® represents the starting point of our approach. Taken systemically, BIOSTERINE® exerts a marked anti-inflammatory action and reduces phlogosis of tissues affected. Its association with other specific, natural principles, make it possible to reach even more remarkable results.
Boswellia extract possesses recognised anti-inflammatory properties and is particularly effective in painful pathologies affecting the musculo-skeletal apparatus. Its activity is attributable to the presence, in its phytocomplex, of particular compounds called boswellic acids. Numerous clinical studies have confirmed its efficacy, comparable to synthetic medicines, yet without causing any side-effects whatsoever.
The idea of including in the formulation both the dry extract with high titration in boswellic acids (75%) as well as the powder of the whole plant has proven to be a successful one. In fact, this association enables to have, on the one hand, adequate supply of “nobler” forms of active constituents (boswellic acids), ensuring efficacy; on the other it makes it possible to have the entire phytocomplex, for a synergistic and, at the same time, “smoother” effect on the organism, thereby ensuring that the produce will be totally free from side-effects also in the long run.
Turmeric: turmeric is used in phytotherapy for the treatment of several pathologies involving inflammations, including ostheoarthritis. Its anti-inflammatory action is attributable in particular to the presence of particular substances called curcuminoids. Research has pointed out that the efficacy of turmeric extract is linked to its activity on several physiological mechanisms involved in the inflammatory process.
Turmeric therefore acts on the inflammation with a 360° mechanism, without causing any side-effect. Some of the fundamental mechanisms involved are as follows:
- a) inhibition of cyclooxygenase-2 and lipoxygenase enzymes, with a resulting reduced production of prostaglandins and other inflammatory chemical mediators;
- b) inhibition of the release of numerous pro-inflammatory cytokines and interleukins;
- c) inhibition of the production of cell adhesion molecules involved in the early phase of the inflammatory cascade;
- d) inhibition of collagen degradation. The idea of including in the formulation both the dry extract, with high titration in curcuminoids (95%), as well as the powder of the entire plant has been a successful one: in fact, this association ensures maximum efficacy and lack of any side-effect whatsoever.
Hyaluronic Acid: its physiological function is to maintain the right level of hydration in the connective tissue. It moreover acts as a cementing substance and as a kind of shock absorbing molecule, as well as being an efficient lubricant (synovial fluid/joints), preventing damage of the tissues. Its function is therefore fundamental for the health and functionality of the skeletal tissue and of the joints.
For this reason, Hyaluronic Acid has been used since it was first discovered to treat joint disorders. Besides the excellent results obtained following its use in intra-articular infiltrations, it has recently been studied to verify its efficacy for oral intake.
Regarding the formulation, Hyaluronic Acid is therefore used in association with Biosterine®, Boswellia and Turmeric, to complete the anti-inflammatory activity of the product. Another activity of Hyaluronic acid has recently been identified, making it particularly useful within the formulation: as a carrier of active molecules to increase bioavailability, once ingested and hydrated, Hyaluronic Acid forms a bioadhesive matrix bringing the active constituents into the solution and promoting their gradual release, saturating the mucosa and increasing contact time between active constituents and the intestinal mucosa itself.
It therefore ensures complete absorption of all constituents present in the phytocomplexes included (Biosterine®, Boswellia e Curcuma), optimizing their bioavailability and enhancing their efficacy.
The ideal form of intake of such plant ingredients is represented by swallowable tablets.